Bifemelane Protects Cultured Cortical Neurons Against N-Methyl-D-aspartate Receptor-Mediated Glutamate Cytotoxicity
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چکیده
منابع مشابه
Corticosterone acutely prolonged N-methyl-d-aspartate receptor-mediated Ca2+ elevation in cultured rat hippocampal neurons.
This work reports the first demonstration that corticosterone (CORT) has a rapid and transient effect on NMDA receptor-mediated Ca2+ signaling in cultured rat hippocampal neurons. Using single cell Ca2+ imaging, CORT and agonists of glucocorticoid receptors were observed to modulate the NMDA receptor-mediated Ca2+ signals in a completely different fashion from pregnenolone sulfate. In the absen...
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The functional roles played by metabotropic glutamate receptors in the neostriatum is just beginning to be examined. One possibility, raised by previous studies, is that metabotropic glutamate receptors act to modulate responses mediated by ionotropic glutamate receptors. In the present study, we examined this possibility in a neostriatal brain slice preparation using intracellular recording an...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1254/jjp.76.313